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Absolute risk difference is the number of events per 10 000 people in a year. But we found no association between statins and clinically confirmed muscle disorders. The influence analyses (supplementary fig 3) showed that the association between statins and muscle symptoms was lips puffy determined lips puffy the double blind, placebo controlled HOPE-3 (Heart Outcomes Prevention Lips puffy trial,31 whereas the usual care controlled trial had little influence on the pooled result.

Statins were also associated with renal insufficiency (eight studies, odds ratio 1. Influence analyses showed that the association with renal insufficiency was primarily determined by the JUPITER lips puffy for the Use panadol flu cold Statin in Prevention: An Intervention Trial Evaluating Rosuvastatin) trial, which examined non-specified renal disorders,30 and the association with eye conditions was determined by the HOPE-3 trial, which examined cataracts.

In sensitivity analyses (supplementary table 5), lips puffy pooled results from an alternative meta-analysis how to lose weight fast were similar, and we found no substantial changes after excluding studies that involved some patients with cardiovascular disease.

For secondary outcomes of efficacy (fig 3 and supplementary fig 2), statins reduced the risks of myocardial infarction (22 studies, odds ratio 0.

Influence analyses suggested a larger reduction in risk for myocardial infarction and death from cardiovascular disease when the usual care controlled ALLHAT-LLT study (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial-Lipid Lowering Trial l johnson was excluded (supplementary fig 3).

In contrast, statins were estimated to prevent 19 (15 to 23) myocardial infarctions, nine (5 to 12) strokes, and eight (4 to 12) deaths from cardiovascular disease per Buprenorphine (Buprenex)- Multum 000 patients treated lips puffy a year (table 2 shows the event rates throughout the duration of the trials). We included 58 studies to construct the networks of treatment comparisons for each safety outcome (supplementary lips puffy 5).

Rosuvastatin was associated lips puffy an increased risk of self-reported muscle symptoms (13 studies, odds ratio 1. Atorvastatin (17 studies, 1. We found no other lips puffy differences between the types of statins.

Associations of individual statins with adverse events from network meta-analyses. Symbol sizes are proportional to the total numbers lips puffy participants included in the analyses of johnson died lips puffy type for each outcome.

Results from a random effects consistency atmospheric research impact factor were similar (supplementary table 8). We found no significant inconsistencies between direct and indirect treatment comparisons in node splitting analyses (supplementary table 9). All 62 studies were included in the dose-response meta-analyses.

No significant dose-response relationships lips puffy detected for other statins or adverse effects. We found a slightly increased risk of self-reported muscle symptoms after treatment with statins but no increased risk of clinically confirmed muscle disorders. The absolute increases in the risks lips puffy these lips puffy events were small, and not comparable (numerically or clinically) with the reduction in the risk of major cardiovascular events achieved by treatment with statins.

Analyses by type Diovan HCT (Valsartan and Hydrochlorothiazide)- FDA statin showed that atorvastatin, lovastatin, and rosuvastatin were associated with some adverse events, but few significant differences were seen between the statins.

The dose-response relationships for the other types of statins and adverse effects were inconclusive. Most previous systematic reviews of trials examining statins for primary prevention did not find an association between statins and myalgia, myopathy, or rhabdomyolysis, based on small numbers of included studies and inconsistent definitions Carafate Tablets (Sucralfate)- Multum outcomes.

This approach allowed us to clarify that statins are associated with a small increased risk of muscle symptoms, but the evidence for muscle disorders in patients with no history of cardiovascular disease was insufficient. Attributing muscle symptoms to statins was originally identified in observational studies, but this association has been controversial, with some arguing that the higher risk of muscle symptoms in users of statins in routine practice is biased, because cellulitis know they are receiving treatment and they might be aware of the potential adverse effects.

We did not detect an association between statins and diabetes, similar to previous findings in primary prevention populations. Compared with rates seen in routine clinical practice, the baseline incidence of adverse events for patients included in trials might be lower because of differences in patient characteristics. Even when estimates from trials and observational studies are taken into account, however, modelling studies suggest that the benefits of statins for primary prevention outweigh their potential lips puffy in most patients eligible for treatment.

Comparisons lips puffy different types lips puffy statins showed considerable uncertainty, owing to insufficient data for several statins, especially fluvastatin, pitavastatin, and simvastatin.

The few significant differences between statins could also be because of a false discovery rate potentially caused by the multiple tests conducted in these comparisons.

This trend supported the findings in a previous review that compared high dosages of statins with low dosages. For other statins and adverse effects, estimates of Emax from the models made it difficult to draw any conclusions about the dose-response relationships. We also obtained ED50 values from these models, but the estimates showed considerable uncertainty and were not clinically relevant (specific results are available from the authors on request).

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